Yazar "Baltaş, Nimet" için listeleme
-
a-Glucosidase inhibition properties of novel azaphthalocyanines containing vanillin
Kantar, Günay Kaya; Baltaş, Nimet; Şahin, Onur; Şaşmaz, Selami (Natl Inst Science Communication & Policy Research, 2023)Vanillin substituted novel zinc(II) azaphthalocyanines (ZnAzaPcs) have been synthesized and investigated for their & alpha;-glucosidase inhibition properties. The new compounds (1, 2, 1a and 2a) have been characterised ... -
Adsorption of Reactive Red 120 from aqueous solutions by cetylpyridinium-bentonite
Tabak, Ahmet; Baltaş, Nimet; Afşin, Beytullah; Emirik, Mustafa; Çağlar, Bülent; Eren, Erdal (Wiley, 2010)BACKGROUND: The removal of Reactive Red 120 (RR 120) from aqueous solutions using cetylpyridinium modified Resadiye bentonite (CP-bentonite) prepared by ion exchange was investigated with particular reference to the effects ... -
Biochemical properties of partially purified polyphenol oxidase and phenolic compounds of Prunus spinosa L. subsp dasyphylla as measured by HPLC-UV
Baltaş, Nimet; Pakyıldız, Semra; Can, Zehra; Dinçer, Barbaros; Kolaylı, Sevgi (Taylor & Francis Inc, 2017)Polyphenol oxidase (PPO) enzyme was extracted from Prunus spinosa L. subsp. dasyphylla plum, partially purified by acetone precipitation, and its biochemical properties were investigated. Different substrates (p-coumaric ... -
Bioevaluation of synthetic pyridones as dual inhibitors of alpha-amylase and alpha-glucosidase enzymes and potential antioxidants
Saleem, Faiza; Khan, Khalid Mohammed; Ullah, Nisar; Özil, Musa; Baltaş, Nimet; Hameed, Shehryar; Salar, Uzma; Wadood, Abdul; Rehman, Ashfaq Ur; Kumar, Mukesh; Taha, Muhammad; Haider, Syed Moazzam (Wiley, 2022)Herein, a library of novel pyridone derivatives 1-34 was designed, synthesized, and evaluated for alpha-amylase and alpha-glucosidase inhibitory as well as antioxidant activities. Pyridone derivatives 1-34 were synthesized ... -
Chemical analysis and biological activity of the essential oils and extracts of two liverwort species growing in Turkey
Çelik, Gonca; Şahin, Hüseyin; Baltaş, Nimet; Batan, Nevzat; Karaoğlu, Şengül Alpay; Yaylı, Nurettin (University Belgrade, 2023)The aim of this study was to investigate the chemical composition of the essential oils (EOs) from two Diplophyllum species and to evaluate their bioactivity potential [antimicrobial, antioxidant, anti-urease, anti-xanthine ... -
Cholesterol forms and traditional lipid profile for projection of atherogenic dyslipidemia: lipoprotein subfractions and erythrocyte membrane cholesterol
Uydu, Hüseyin Avni; Bostan, Mehmet; Atak, Mehtap; Yılmaz, Adnan; Demir, Adem; Akcan, Buket; Sümer, Fatih; Baltaş, Nimet; Karadağ, Zakir; Uğurlu, Yavuz; Örem, Asım (Springer, 2014)Atherogenic dyslipidemia characterized by abnormal changes in plasma lipid profile such as low high-density lipoprotein (HDL) and increased triglyceride (TG) levels is strongly associated with atherosclerotic diseases. We ... -
Developing a scaffold for urease inhibition based on benzothiazoles: Synthesis, docking analysis, and therapeutic potential
Özil, Musa; Tuzcuoğlu, Özge; Emirik, Mustafa; Baltaş, Nimet (Wiley-V C Verlag GMBH, 2021)The synthesis, in silico molecular docking, and in vitro urease inhibition studies of a novel series of benzothiazole derivatives are reported. The title compounds in the two series, namely, 2-({5-[(benzothiazol-2-ylthio ... -
Effect of propolis in gastric disorders: inhibition studies on the growth of Helicobacter pylori and production of its urease
Baltaş, Nimet; Karaoğlu, Şengül Alpay; Tarakcı, Cemre; Kolaylı, Sevgi (Taylor & Francis Ltd, 2016)There is considerable interest in alternative approaches to inhibit Helicobacter pylori (H. pylori) and thus treat many stomach diseases. Propolis is a pharmaceutical mixture containing many natural bioactive substances. ... -
Hydrazinyl thiazole linked indenoquinoxaline hybrids: Potential leads to treat hyperglycemia and oxidative stress; Multistep synthesis, alpha-amylase, and antioxidant activities
Hameed, Shehryar; Khan, Khalid Mohammed; Salar, Uzma; Özil, Musa; Baltaş, Nimet; Saleem, Faiza; Qureshi, Urooj; Taha, Muhammad; Ul-Haq, Zaheer (Elsevier, 2022)A library of hydrazinyl thiazole-linked indenoquinoxaline hybrids 1-36 were synthesized via a multistep reaction scheme. All synthesized compounds were characterized by various spectroscopic techniques including EI-MS ... -
Indenoquinoxaline-phenylacrylohydrazide hybrids as promising drug candidates for the treatment of type 2 diabetes: In vitro and in silico evaluation of enzyme inhibition and antioxidant activity
Hameed, Shehryar; Saleem, Faiza; Özil, Musa; Baltaş, Nimet; Salar, Uzma; Ashraf, Sajda; Ul-Haq, Zaheer; Taha, Muhammad; Khan, Khalid Mohammed (Elsevier, 2024)Existing drugs that are being used to treat type-2 diabetes mellitus are associated with several side effects; thus, exploring potential drug candidates is still an utter need these days. Hybrids of indenoquinoxaline and ... -
Indole-pyridine carbonitriles: multicomponent reaction synthesis and bio-evaluation as potential hits against diabetes mellitus
Solangi, Mehwish; Khan, Khalid Mohammed; Ji, Xingyue; Özil, Musa; Baltaş, Nimet; Salar, Uzma; Khan, Alamgir; Ul-Haq, Zaheer; Meghwar, Herchand; Taha, Muhammad (2023)Background: Diabetes mellitus is a significant health disorder; therefore, researchers should focus on discovering new drug candidates. Methods: A series of indole-pyridine carbonitrile derivatives, 1-34, was synthesized ... -
Inhibition properties of propolis extracts to some clinically important enzymes
Baltaş, Nimet; Yıldız, Oktay; Kolaylı, Sevgi (Taylor & Francis Ltd, 2016)The present study was conducted to envisage inhibition effects of propolis on the crucial enzymes, urease, xanthine oxidase (XO) and acetylcholinesterase (AChE). Some of the antioxidant properties of the propolis samples ... -
Metabolite profiling of Althaea officinalis by HPLC-DAD-MS with in silico and in vitro analysis for therapeutic potential
Turumtay, Emine Akyüz; Demir, Adem; Çetiz, Mehmet Veysi; Uudağ, Emre Berk; Baltaş, Nimet; Yaman, Burak; Yaman, Mehmet; Emirik, Mustafa; Turumtay, Halbay (Springer, 2023)Althaea officinalis L. has been widely used traditionally as an herbal tea and for the treatment of cough, mucous membrane irritation, colds, and inflammation. Parts of the plant extracts were analyzed using HPLC-DAD and ... -
Microwave-assisted synthesis and investigation of xanthine oxidase inhibition of new phthalonitrile and phthalocyanines containing morpholino substituted 1,2,4-triazole-3-one
Kantar, Günay Kaya; Baltaş, Nimet; Menteşe, Emre; Şaşmaz, Selami (Elsevier Science Sa, 2015)Novel phthalonitrile and zinc (II) phthalocyanines containing pharmacological active molecules like morpholine and triazole were prepared and characterized. the new compounds were obtained by both microwave assisted and ... -
Multicomponent diastereoselective synthesis of tetrahydropyridines as α-amylase and α-glucosidase enzymes inhibitors
Saleem, Faiza; Shamim, Fariha; Özil, Musa; Baltaş, Nimet; Salar, Uzma; Ashraf, Sajda; Ul-Haq, Zaheer; Taha, Muhammad; Solangi, Mehwish; Khan, Khalid Mohammed (2023)Background: Researchers seeking new drug candidates to treat diabetes mellitus have been exploring bioactive molecules found in nature, particularly tetrahydropyridines (THPs). Methods: A library of THPs (1–31) were ... -
New potential monotherapeutic candidates for helicobacter pylori: Some pyridinazo compounds having both urease enzyme inhibition and anti-helicobacter pylori effectiveness
Kantar, Cihan; Baltaş, Nimet; Karaoğlu, Şengül Alpay; Şaşmaz, Selami (Springer, 2021)To contribute to the monotherapeutic approach to Helicobacter pylori, some new pyridinazo compounds containing natural phenols such as eugenol and guaiacol were synthesized and their antioxidant capacities, urease enzyme ... -
Novel zinc(II)phthalocyanines bearing azo-containing schiff base: Determination of pKa values, absorption, emission, enzyme inhibition and photochemical properties
Kantar, Cihan; Mavi, Vildan; Baltaş, Nimet; İslamoğlu, Fatih; Şaşmaz, Selami (Elsevier Science Bv, 2016)Azo-containing schiff bases are well known and there are many studies about their various properties in literature. However, phthalocyanines bearing azo-containing schiff bases, their spectral, analytical and biological ... -
Partial purification and characterization of lipase from Geobacillus stearothermophilus AH22
Ekinci, Arife Pınar; Dinçer, Barbaros; Baltaş, Nimet; Adıgüzel, Ahmet (Taylor & Francis Ltd, 2016)The lipase was partially purified by ion exchange chromatography and gel filtration column chromatography, and was characterized from Geobacillus stearothermophilus AH22 strain. the lipase was purified 18.3-folds with 19.7% ... -
Polyphenol oxidase properties, anti-urease, and anti-acetylcholinesterase activity of Diospyros lotus L. (Plum Persimmon)
Faiz, Özlem; Baltaş, Nimet (Taylor & Francis Inc, 2017)Diospyros lotus fruit polyphenol oxidase was purified using affinity chromatography, resulting in a 15-fold enrichment in specific activity. the purified enzyme, having 16.5 kDa molecular weight on sodium dodecyl ... -
Properties of Antioxidant and Anti-Inflammatory Activity and Phenolic Profiles of Şevketi Bostan (Cnicus benedictus L.) Cultivated in Aegean Region from Turkey
The aim of this work was to evaluate the phenolic profiles and anti-inflammatory, antioxidant and gastro-protective activities of Cnicus benedictus L., a type of milk thistle cultivated in Turkey. The total phenolic content ...